Bold & Rigorous

Develop ambitious research questions and address them with rigorous and robust methods toward generating reproducible findings that contribute to advancing translation.

Example approaches:

• Bold Scientific Approaches: Explore ambitious research goals that have the potential to produce major advances and/or paradigm shifts. These may be in areas of research that have been historically intractable or where there are high risks of failure.
• Rigor and Reproducibility: Employ rigorous and robust approaches to generate reproducible findings and high-quality FAIR (findable, accessible, interoperable, reusable) data that will enable the research to advance translational progress regardless of whether the initial research objective is met (e.g., learning from failures). To the maximum extent possible, disseminate all parameters utilized to conduct the research (e.g., materials, subjects), research methods and conditions, authentication of reagents and biological resources, data sets, metadata, analytic approaches and statistical tools used for experimentation and data interpretation, results and conclusions, to facilitate reproducibility and/or inform future study designs.
• Organizational Environments: Enable rigorous testing of bold, paradigm-challenging ideas, including high-risk high-reward opportunities. Encourage reporting of information necessary for reproducibility toward informing future studies.